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Tuesday, April 24 • 10:40am - 11:00am
In-Vitro And In-Silico Synthesis Of Anticancer Compounds To Halt Rapid Cell Division And Cleave DNA

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Combretastatin A-4 is a naturally occurring compound isolated from the South African bushwillow Combretum caffrum. A variety of its analogs, such as 3,5-diaryl-4-iodopyrrole-2-carboxylate derivatives, have demonstrated anti-mitotic, anticancer, and antibiotic properties. The formation of these analogs serve as useful intermediates to synthesize more complex heterocyclic systems in addition to being the core structure of all lamellarins. Different methods consist of a 3-step one-pot procedure including a halogenation, and others contain a purification step prior to the halogenation. Both methods have acquired decently high yields (53% - 88%) with the one-pot reaction on the higher end. Not only does the one-pot method seem to be more efficient, yet it is faster and contains fewer individual steps. Furthermore, these analogs are to be tested both in-vivo and in-silico.

Tuesday April 24, 2018 10:40am - 11:00am PDT
202 Zeis Hall

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