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Spring Symposium on UR and Community Engagement has ended
Tuesday, April 24 • 12:00pm - 1:30pm
Analysis And Investigation Of Aziridines

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This research examined, aziridines and their properties. Although aziridines are structurally similar to Beta-lactams, a broad group of antibiotics, they are more unstable. Investigating aziridines as a modification of Beta-lactams could give more insight into the functionality of Beta-lactams and open up a potential new branch of antibiotics. The Department of Chemistry at the Science University of Tokyo used the Corey-Chayovsky Aziridation Reaction to investigate the enantioselective synthesis of aziridnes from amines and alkyl halides by using camphor-derived chiral sulfide mediator. Thus, demonstrating the aziridation of imines with alkyl bromides with the imino Corey-Chayovsky reaction under the conditions of a chiral sulfide. These findings give more possibilities of modification for the proposed research. The proposed study was to investigate 2-phenyl-1-(3,4,5-trimethoxybenzyl) aziridine. The starting reaction of benzylamine and 3,4,5-trimethoxy benzaldehyde was used to create the imine, (E)-1-phenyl-N-(3,4,5-trimethoxybenzyl) methanimine. After this first reaction, the (E)-1-phenyl-N-(3,4,5-trimethoxybenzyl) methanimine was reacted with a carbene to create 2-phenyl-1-(3,4,5-trimethoxybenzyl) aziridine.


Tuesday April 24, 2018 12:00pm - 1:30pm
Sherrill Center Concourse